A scientific study titled ‘Cannabidiol Modulates Serotonergic Transmission and Reverses Both Allodynia and Anxiety-Like Behavior in a Model of Neuropathic Pain‘ has found firm evidence that Cannabidiol (CBD) reduces neuropathic pain, in addition to reducing the anxiety caused by neuropathic pain. This study was published in early 2019, and was a collaboration between several major universities including McGill University in Montreal, Washington State University, Università degli Studi della Campania Luigi Vanvitelli in Naples, and San Raffaele Scientific Institute and Vita Salute University in Milan.
In this study an experiment was conducted on rats which had neuropathic pain. It was found that rats with neuropathic pain had decreased Serotonin firing activity, anxiety-like behavior, and mechanical allodynia, which is a painful condition associated with neuropathy where pain is caused by stimuli which usually do not cause pain, similar to the way a sunburn is painful even if it is lightly touched.
The rats were treated with CBD for a week, and it was found that their mechanical allodynia was decreased, their anxiety-like behavior decreased, and Serotonin firing activity normalized. In other words, this study found that CBD rectified a lot of the problems associated with neuropathic pain.
Ultimately, the scientists conclude that CBD has analgesic (pain relieving) effects for neuropathic pain, and further only low-dose CBD is required to significantly diminish neuropathic pain.
The scientists dived into the mechanisms behind these benefits, and concluded that CBD provides analgesia for neuropathic pain via TRPV1 activation, with TRPV1 being a receptor that is related to the feeling of scalding heat and pain, in addition to being an important modulator for the body’s response to noxious environmental stimuli.
As for the anti-anxiety effects, the scientists found that CBD accomplished this via interacting with one of the Serotonin receptors, specifically 5-HT1A.
Overall, these results are critically important since neuropathic pain cannot be treated by typical painkillers, such as anti-inflammatory drugs and opioids. In-fact, there is no officially recognized efficacious treatment option for neuropathic pain. Gabapentin and Pregabalin are perhaps the most widely distributed medicines for neuropathic pain, but often these don’t work.
Therefore, the world needs a painkiller for neuropathic pain, and this scientific study suggests that CBD could be the solution. Of course, far more research needs to be done, but that being said, there are many more studies than the one highlighted in this article which discuss how CBD could be efficacious for treating neuropathic pain. In other words, the use of CBD for treating neuropathic pain is a very active area of research, and the information in this article is just the tip of the iceberg.